Chronic granulomatous disease treatment

CGD Treatment & Management. The best treatment plan for CGD is to prevent infections from occurring. Special preventative antibiotics are a mainstay of treatment for CGD. These greatly reduce the chances of infection. People with CGD should also avoid swimming other than in chlorinated pools What are the treatments for chronic granulomatous disease (CGD)? Doctors use several different drugs to manage the symptoms of CGD: Antibiotics: Antibacterial drugs are used both for prophylaxis (prevention) and for treatment of acute infections Antifungals: Antifungal drugs such as itraconazole may be used both for prophylaxis and for treatment of acute infection Modern therapy for chronic granulomatous disease (CGD) includes aggressive and prolonged administration of antibiotics and prednisone. Treatment for inflammatory and autoimmune complications in..

ACTIMMUNE ® is part of a drug regimen used to treat Chronic Granulomatous Disease, or CGD. CGD is a genetic disorder, usually diagnosed in childhood, that affects some cells of the immune system and the body's ability to fight infections effectively Bone marrow transplant is another treatment option for some people with severe symptoms of CGD. Bone marrow transplantation can cure CGD. However, this therapy is extremely complex, and transplant..

The main focus of conventional treatment for CGD is prevention and management of infections and inflammatory complications. Widespread antibiotic prophylaxis was introduced from the 1970s;22sulphamethoxazole‐trimethoprim is preferred because of its safety and efficacy, and because of the intracellular action However, durable clinically significant correction of chronic granulomatous disease with gene therapy awaits improved methods for gene transfer, targeting of hematopoietic stem cells, and control.. Gene therapy is currently being studied as a possible treatment for chronic granulomatous disease. CGD is well-suited for gene therapy since it is caused by a mutation in single gene which only affects one body system (the hematopoietic system ) Management of inflammatory complications of chronic granulomatous disease (CGD) is challenging. The aim of this study was to assess safety, with a focus on infections, and effectiveness of tumor necrosis factor alpha (TNF-α) blockers in CGD patients. A retrospective, single-center cohort study of CGD patients treated by anti-TNF-α agents at Necker-Enfants Malades University Hospital (Paris. Management: Treatment of manifestations: A definitive microbiologic diagnosis is essential to proper treatment of infections. Newer azole drugs (voriconazole, posaconazole, isovuconazole) have expanded therapeutic options for fungal infections. Long courses of antimicrobials are often needed for adequate treatment

People with chronic granulomatous disease experience serious bacterial or fungal infection every few years. An infection in the lungs, including pneumonia, is common. People with CGD may develop a serious type of fungal pneumonia after being exposed to dead leaves, mulch or hay Chronic granulomatous disease is usually managed with antibiotic and antifungal medications to treat and prevent infection. Corticosteriods may be used to shrink granulomas (areas of inflamed tissue). Treatment may also include a medication called Actimmune (also known as interferon gamma-1b)

The only curative treatment for chronic granulomatous disease is hematopoietic stem cell transplantation from a human leukocyte antigen compatible donor. Unfortunately, this option usually carries too much risk to be considered as recommended in all patients with chronic granulomatous disease A 37-year-old woman with chronic granulomatous disease (CGD) was admitted to the hospital while pregnant at 21 weeks gestational age (GA) with 2 weeks of progressive cough and shortness of breath. She had been diagnosed with autosomal recessive NCF1 (p47phox)-deficient CGD at age 9 years Antibiotics are used to treat the disease, and may also be used to prevent infections. A medicine called interferon-gamma may also help reduce the number of severe infections. Surgery may be needed to treat some abscesses. The only cure for CGD is a bone marrow or stem cell transplant Chronic granulomatous disease (CGD) is a primary immunodeficiency of phagocyte function due to defective NADPH oxidase (phox). Compared with the common types of CYBB/gp91phox, NCF1/p47phox, and CYBA/p22phox deficiency, NCF4/p40phox deficiency is a mild and atypical form of CGD without invasive bacterial or fungal infections. It can be diagnosed using serum-opsonized E.coli as a stimulus in. Chronic granulomatous disease (CGD) is a genetic disorder in which white blood cells called phagocytes are unable to kill certain types of bacteria and fungi. People with CGD are highly susceptible to frequent and sometimes life-threatening bacterial and fungal infections. NIAID's research on CGD aims to improve diagnosis, explore new treatments and preventions, and facilitate genetic counseling

Chronic granulomatous disease (CGD) is a primary immunodeficiency disorder of phagocytes that results from the impaired killing of fungi and bacteria, which can lead to severe, recurrent, and life-threatening infections. {{configCtrl2.info.metaDescription} Chronic granulomatous disease, also known as Bridges - Good syndrome and Quie syndrome is a hereditary disease that occurs when certain cells of the immune system encounter difficulties in forming reactive oxygen compounds (especially radical superoxide) due to damage to phagocytes, when such reactive compounds are needed to kill pathogens

Chronic Granulomatous Disease Symptoms, Diagnosis & Treatment

Chronic Granulomatous Disease (CGD) Management and

  1. Chronic granulomatous disease (CGD) is a primary immunodeficiency caused by defects in any of the five subunits of the NADPH oxidase complex responsible for the respiratory burst in phagocytic leukocytes. Patients with CGD are at increased risk of life-threatening infections with catalase-positive b
  2. Treatment for chronic granulomatous disease (CGD) includes: preventative (prophylactic) antibiotics and antifungals on a long-term basis ; infection management with antibacterial or antifungal medications; gamma-interferon therapy to help boost the immune system to help fight infection
  3. Immediately after bronchoscopy, treatment was initiated with intravenous cefepime 2 g every 8 hours, oral oseltamivir 75 mg twice daily, and intravenous TMP/SMX 15 mg/kg daily divided every 8 hours. Voriconazole was initiated at 6 mg/kg intravenously every 12 hours for 2 doses, followed by 300 mg (4 mg/kg) orally twice daily
  4. ACTIMMUNE ® is part of a drug regimen used to treat Chronic Granulomatous Disease, or CGD. CGD is a genetic disorder, usually diagnosed in childhood, that affects some cells of the immune system and the body's ability to fight infections effectively. CGD is often treated (though not cured) with antibiotics, antifungals, and ACTIMMUNE
  5. Treatment of chronic granulomatous disease (CGD) with myeloablative bone marrow transplantation is considered risky. This study investigated complications and survival according to different risk factors present at transplantation. The outcomes of 27 transplantations for CGD, from 1985 to 2000, reported to the European Bone Marrow Transplant.
  6. Chronic granulomatous disease treatment options, diagnosis, and images at Epocrates Online, the leading provider of drug and disease decision support tools

Chronic Granulomatous Disease Treatment & Management

Modern therapy for chronic granulomatous disease (CGD) includes aggressive and prolonged administration of antibiotics and prednisone. [ 28] T Treatment for inflammatory and autoimmune.. HSCT is a curative treatment for patients with CGD that provides neutrophils from a donor with functional nicotinamide adenine dinucleotide phosphate (NADPH) and superoxide anion production. It is a high-risk procedure associated with morbidity and mortality, usually related to graft-versus-host disease Chronic granulomatous disease treatment approach, diagnosis, and images at Epocrates Online, the leading provider of drug and disease decision support tools Are there natural treatment(s) that may improve the quality of life of people with Chronic Granulomatous Disease? Here you can see if there is any natural remedy and/or treatment that can help people with Chronic Granulomatous Disease Itraconazole prophylaxis appears to be an effective and well-tolerated treatment that reduces the frequency of fungal infections in chronic granulomatous disease, but monitoring for long-term.

Chronic Granulomatous Disease Treatment and Management Tip

  1. Treatment of Chronic Granulomatous Disease. Early diagnosis of infection and prompt, aggressive use of appropriate antibiotics is the best way to treat CGD infections. Initial therapy with antibiotics aimed at the usual suspects makes sense while waiting for results of cultures, but it is important to try to identify the specific infection and.
  2. antifungal treatment, chronic granulomatous disease, conventional treatment, hematopoietic stem cell transplantation, infections, inflammation, morbidity, mortality Search for Similar Articles You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search
  3. Chronic granulomatous disease treatment. Chronic granulomatous disease is treated with: Aggressive antibiotic therapy, intravenously if necessary, and preferably with a specific rather than a broad-spectrum antibiotic; Transfusion of plasma; Antibiotic prophylaxis with a combination of trimethoprim and sulfamethoxazol
  4. Conventional treatment of CGD comprises antibacterial and antifungal prophylaxis with cotrimoxazole and azoles, as well as immunosuppressive therapy. 7 Although prophylaxis has strongl

What is chronic granulomatous disease (CGD)? Chronic granulomatous disease (CGD) is an inherited disorder that affects the immune system. In people with this condition, phagocytes - which are types of white blood cells of the cellular immune system such as neutrophils and macrophages - are unable to attack and destroy certain microbes Chronic granulomatous disease (CGD) is a primary immune deficiency disorder of the phagocytes. In this disorder, phagocytic cells (polymorphonuclear leukocytes and monocytes) cannot produce active. Treatment of chronic granulomatous disease is continuous prophylactic antibiotics, particularly trimethoprim/sulfamethoxazole 160/800 mg orally twice a day. Oral antifungals are given as primary prophylaxis or are added if fungal infections occur even once; most useful ar Chronic granulomatous disease 1. Chronic Granulomatous disease Jintana Chataroopwijit 10 Feb 2017 2. Content • Introduction • Function of NADPH oxidase • Molecular genetic aspect • Clinical manifestation • Diagnosis and investigation • Treatment 3 Modern therapy for chronic granulomatous disease (CGD) which includes aggressive and prolonged administration of antibiotics and prednisone. Treatment for inflammatory and autoimmune complications in patients with CGD is problematic because most agents are immune suppressive and immunity is already impaired in patients with CGD

Chronic Granulomatous Disease: Life Expectancy, Treatment

Treatment of chronic granulomatous disease consists of continuous antibiotic therapy to help prevent infections, such as trimethoprim and sulfamethoxazole to protect against bacterial infections, and itraconazole for anti-fungal protection. Infections usually require additional antibiotics Treatment is with antibiotics, antifungal drugs, and interferon. The disease was first described in the 1950s as a fatal granulomatosus of childhood. More than half of cases of chronic.. Chronic granulomatous disease (CGD) is a primary immunodeficiency caused by defects in any of the five subunits of the NADPH oxidase complex responsible for the respiratory burst in phagocytic.

Progress in treating chronic granulomatous disease

Chronic Granulomatous Disease Treatment. The goal of treating CGD is to control the symptoms. Children with CGD may need aggressive treatment for their infections. Sometimes, doctors prescribe antibiotics even when a child doesn't have any infections to prevent them Chronic granulomatous disease (CGD) patients and female carriers of X-linked CGD have been reported to demonstrate lupus-like rashes that share overlapping clinical and histologic features with the rashes seen in true discoid lupus erythematosus and tumid lupus erythematosus without CGD. This lupus-like rash is more commonly observed in adulthood and in carriers, possibly secondary to the high. Chronic Granulomatous Disease List of authors. Mohsen Esfandbod, M.D., and Maryam Kabootari, M.D. A 12-year-old boy was admitted to the hospital because of fever, chills, sweats, productive cough. Chronic granulomatous disease (CGD) is a primary immunodeficiency defined by mutations in the NADPH oxidase complex leading to reduced superoxide production, increased susceptibility to infection, chronic inflammation, and recurring abscess and granuloma formation

Chronic granulomatous disease can be cured by bone marrow transplant but this procedure is complex and this option is not available to all patients. What is the prognosis for patients with chronic granulomatous disease? Due to advances in medical technology/treatment, the prognosis for chronic granulomatous disease patients has improved. Created by world-class clinical faculty, Learning in 10 (LIT) Reviews covers topics in the United States Medical Licensing Exam (USMLE) Step 2CK examination... NIH scientists provide an overview of chronic granulomatous disease, describe its symptoms, and discuss how treatments have advanced. They also explain how s.. Lung diseases are a common cause of illness and death, with every one out of seven people being affected by some form or the other, worldwide. Chronic lung diseases include the onslaught of pneumonia, pulmonary embolism, asthma and granulomatous lung disease. Granulomas in the lungs cause prolonged lung damage

Pediatric Chronic Granulomatous Disease Treatment

What Is Chronic Granulomatous Disease? It is a genetic disorder wherein phagocytes- cells of immune system fails to function properly. Such leads to serious and ongoing infection. What Are The Alternative Names Of Chronic Granulomatous Disease? Chronic granulomatous disease is also known by the following names: Fatal granulomatosis of childhood treatment of chronic granulomatous disease with nonmyeloablative conditioning and a t-cell-depleted hematopoietic allograft m itchell e. h orwitz, m.d., a. j ohn b arrett, m.d., m argare About Chronic Granulomatous Disease Chronic granulomatous disease is an inherited abnormality of certain cells of the immune system that normally kill bacteria (phagocytic cells). It causes recurrent infection by certain types of bacteria

Seger RA (2010) Chronic granulomatous disease: recent advances in pathophysiology and treatment. Neth J Med 68: 334-340. Neth J Med 68: 334-340. [omicsonline.org A form of chronic granulomatous disease, a primary immunodeficiency characterized by severe recurrent bacterial and fungal infections, along with manifestations of chronic granulomatous inflammation. It results from an impaired ability of phagocytes to mount a burst of reactive oxygen species in response to pathogens Chronic granulomatous disease (CGD) is a diverse group of hereditary diseases in which certain cells of the immune system have difficulty forming the reactive oxygen compounds (most importantly, the superoxide radical) used to kill certain ingested pathogens.This leads to the formation of granulomata in many organs.CGD affects about 1 in 200,000 people in the United States, with at least 20. Treatment of patients with chronic granulomatous disease includes: Prevention of infections by immunization and exclusion of contacts with possible sources of infection. Prophylactic continuous use of trimethoprim-sulfamethoxazole at a dose of 5 mg / kg per day for trimethoprim and... As early as. Gene therapy - is being studied as a treatment for chronic granulomatous disease. Experimental trials on 2 patients had yielded promising results (clearance of pre-existing infections and.

Chronic granulomatous disease - Wikipedi

For the treatment of chronic granulomatous disease may be assigned: Antibiotics - used for prevention and treatment of infections; Interferon gamma - It reduces the likelihood of infection, but is ineffective in the presence of active infection. Bone marrow transplantation. One of the best options for the treatment of chronic granulomatous. Chronic granulomatous disease Treatment In order to treat a person with CGD, the disease should be first diagnosed early so that antibiotics can be prescribed immediately and keep an infection from happening. Also, the patient must be educated about his or her condition so that treatment can be given when an infection comes about. Doctors. BACKGROUND Hematopoietic stem cell transplantation (HSCT) can cure chronic granulomatous disease (CGD), but it remains debated whether all conventionally treated CGD-patients benefit from HSCT. METHODS We retrospectively analyzed 104 conventionally treated CGD-patients, of whom 50 patients underwent HSCT. RESULTS On conventional treatment, 7 patients (13%) died after a median time of 16.2. SUMMARY: Several lines of evidence now suggest that stem cell transplantation should be the preferred treatment of choice in severe CGD, if there is an available donor. This should be performed as.. Background —In several diseases there is a relation between deficiency of neutrophil granulocytes and granulomatous lesions. Recently, in glycogen storage disease type Ib, this relation has been supported by the beneficial effect of treatment of enteritis with granulocyte-macrophage colony stimulating factor. Aim —To investigate whether chronic granulomatous disease could be treated.

over the counter treatment for chronic granulomatous disease. A 39-year-old member asked: treatment options for chronic granulomatous disease? thanks! Dr. Cindy Juster answered. 35 years experience Pediatrics. Quite a few!: Cgd is an immune deficiency that leads to frequent bacterial and fungal infections. Current treatment can include. Doctors for Chronic Granulomatous Disease in Moonalingal, Calicut - Book Doctor Appointment, Consult Online, View Doctor Fees, User Reviews, Address and Phone Numbers of Doctors for Chronic Granulomatous Disease | Lybrat The chronic form causes weight loss, fever and breathing problems. Most people slowly recover, but this form can lead to destruction of lung tissue and eventual death. The progressive form causes fever and weakness and may also cause enlargement of the lymph nodes, spleen and liver. Without treatment, this form is usually fatal

Usually, doctors prescribe antibiotics for treating chronic granulomatous disease and preventing infections. Moreover, interferon-gamma also tends to help in preventing severe infections. In order to treat few abscesses, surgery can be needed. The mere cure for the disease is a stem cell or bone marrow transplant The diagnosis of pulmonary involvement is most often made clinically, complemented by radiology (chest roentgenography, computerized tomography or MRI), biopsy, and cultures. Airway obstruction that sometimes complicates infection/granulomatous disease is best diagnosed by pulmonary function tests and by bronchoscopy For lung involvement see - pulmonary manifestations of chronic granulomatous disease. Treatment and prognosis Prophylaxis with daily trimethoprim-sulfamethoxazole and gamma interferon three times a week

Chronic granulomatous disease (CGD) is a rare X-linked or autosomal inherited disease characterized by recurrent life-threatening infections ().The basic defect is an inability of phagocytic cells to produce superoxide anions and hydrogen peroxide, as a result of a defect in one of the subcomponents of the NADPH oxidase in these cells Early treatment: People with Chronic Granulomatous disease are prone to infections. Early treatment of any suspected infection is critical. Graulomas may also for in t..

Infections in Patients with Chronic Granulomatous Disease

The Global Chronic Granulomatous Disease Market is expected to grow at a steady pace over the forecast period. The chronic granulomatous disease is a rare inherited disorder which is passed on. There is no standard treatment for granulomatous rosacea, but granulomatous rosacea is not treated differently than other forms of rosacea. Medications, including antibiotics , anti-inflammatories or isotretinoin may be used Chronic Granulomatous Disease Market is a rare inherited disorder which is passed on from parents to their children. People with this disease have weak immune systems which leave their body.

Chronic granulomatous disease (CGD) is a rare genetic immune disorder that results in recurrent and severe infections, and inflammatory dysregulation. For almost 50% of patients with CGD, this inflammation causes severe inflammatory bowel disease (IBD). However, treatment is long term and challenging as CGD-IBD is prone to relapse, and use of. Chronic granulomatous disease What every physician needs to know: Background. Chronic granulomatous disease (CGD) is a deficiency of microbicidal oxidant production affecting neutrophils. Background: Chronic Granulomatous Disease (CGD) is a heterogeneous clinical presentation immunodeficiency, whose origin can be autosomal recessive or X-linked. In this pathology there is a deficiency in the effector mechanisms of phagocytes. Case study: A review of the patient's medical records was performed, as well as the currently available bibliography For instance, the cost of genetic testing ranges from USD 100 to USD 2,000., Segmentation, The global chronic granulomatous disease market has been segmented into type, diagnosis, treatment, and end user., The market, on the basis of type, is segmented into X-linked chronic granulomatous disease and autosomal recessive chronic granulomatous. Granulomatous inflammation describes a distinct subclass of chronic inflammatory mechanism which predictably arises when the normal inflammatory response involving the neutrophil cannot eliminate the provoking agent. Once these common white blood cells fail to remove the causative agent, the second line of defense comprising the macrophages.

Chronic granulomatous disease (CGD) is usually diagnosed in early childhood (before age 5 years). However, people with milder forms of CGD may not have symptoms until they are in their teens or even adulthood. Common CGD symptoms and signs include: Slow growth in childhood (for example, children being small for their age Chronic granulomatous disease (CGD), also known as Bridges-Good syndrome, chronic granulomatous disorder, and Quie syndrome, is a diverse group of hereditary diseases in which certain cells of the immune system have difficulty forming the reactive oxygen compounds (most importantly the superoxide radical due to defective phagocyte NADPH oxidase) used to kill certain ingested pathogens. This.

This study will determine if the drug infliximab is safe for treating inflammatory bowel disease (IBD) in patients with chronic granulomatous disease (CGD). IBD is an inflammation or irritation of the gut that leads to symptoms such as diarrhea, bloating and stomach cramps Chronic granulomatous disease most often manifests in the head and neck as cervical lymphadenopathy (29,30). This may be a suppurative adenitis from a microbial infection, which manifests at imaging as necrotic lymphadenitis ( Fig 23 ), or it may be lymphadenopathy from chronic granulomatous infiltration, which appears more homogeneous at imaging Core biopsy typically demonstrates a noncaseating granulomatous granuloma, giant cells, chronic inflammation, microabscesses, and necrosis. Tissue should be sent for acid-fast bacillus and fungal stains to rule out tuberculosis or nocardia. An incisional biopsy may be necessary to obtain adequate tissue. Fine-needle aspiration biopsy is useless Chronic granulomatous disease (CGD) is an inherited disorder in which white blood cells lose their ability to destroy certain bacteria and fungi

Chronic Granulomatous Disease Definition Chronic granulomatous disease (CGD) is an inherited disorder in which white blood cells lose their ability to destroy certain bacteria and fungi. Description CGD is an X-linked genetic disease, meaning the defective gene is carried on the X chromosome (one of the sex chromosomes). Females have two copies of the X. Introduction. Chronic granulomatous disease (CGD) is an uncommon inherited immunodeficiency, occurring in about one in 250,000 individuals. Although the genetic basis for this disease is well-known, the expected clinical course and outcome have only partially been defined, owing to its sporadic occurrence -.There are extreme differences in presentation between patients, varying form a.

Chronic Granulomatous Disease - PubMe

Chronic granulomatous disease (CGD) is a primary immunodeficiency caused by failure of superoxide production in phagocytic cells. The disease is characterised by recurrent infections and inflammatory events, frequently affecting the lungs. Improvement of life expectancy now allows most patients to reach adulthood. We aimed to describe the pattern of pulmonary manifestations occurring during. Granulomatous mastitis can be divided into idiopathic granulomatous mastitis (also known as granular lobular mastitis) and granulomatous mastitis occurring as a rare secondary complication of a great variety of other conditions such as tuberculosis and other infections, sarcoidosis and granulomatosis with polyangiitis.Special forms of granulomatous mastitis occur as complication of diabetes

Prostatitis pathophysiology - wikidoc

Chronic granulomatous disease - Symptoms and causes - Mayo

Treatment of chronic granulomatous disease. With timely diagnosis, adequate prevention and proper treatment for children with chronic granulomatous disease, a satisfactory quality of life can be ensured. In case of severe course and risk of development of disability, a radical method of treatment is the allogeneic transplantation of. What is Chronic granulomatous disease? A congenital defect in the killing of phagocytosed bacteria by polymorphonuclear leukocytes, which cannot increase their oxygen metabolism due to dysfunctional NADPH oxidase, either because of defective cytochrome [MIM*233710 and MIM*233690] or other specific factor deficiencies [MIM*233700 and MIM*306400] Granulomatous mastitis falls under the purview of nonlactational mastitis and has classically been described as a rare benign inflammatory breast disease of unknown etiology, 1 leading to designation as idiopathic granulomatous mastitis. 2 It is characterized by breast inflammation resulting in an associated mass; development of abscess. Chronic infectious epididymitis is most frequently seen in conditions associated with a granulomatous reaction; Mycobacterium tuberculosis (TB) is the most common granulomatous disease affecting the epididymis and should be suspected, especially in men with a known history of or recent exposure to TB

Chronic Granulomatous Disease Facts, Symptoms, and Treatment46: Orofacial granulomatosis | Pocket DentistryTrichomoniasis symptoms and Treatment in Men and Women
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